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Michael Lein Selected Research

Ro 28-2653

2/2007Enhanced inhibitory effect of the matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine and etoposide on the prostate carcinoma in the rat Dunning orthotopic tumor model.
9/2005Matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine: tumor-reducing effects on hormone-sensitive prostate cancer in rats.
2/2003Plasma matrix metalloproteinase 9 as biomarker of prostate cancer progression in Dunning (Copenhagen) rats.
3/2002The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model.

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Michael Lein Research Topics

Disease

53Prostatic Neoplasms (Prostate Cancer)
03/2022 - 01/2002
40Neoplasms (Cancer)
01/2021 - 03/2002
13Neoplasm Metastasis (Metastasis)
03/2022 - 12/2003
10Carcinoma (Carcinomatosis)
12/2013 - 05/2003
9Renal Cell Carcinoma (Grawitz Tumor)
12/2014 - 09/2005
4Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
10/2009 - 12/2003
3Bone Resorption
10/2006 - 12/2003
27 Hereditary Prostate Cancer
09/2016 - 02/2011
2Margins of Excision
04/2013 - 12/2012
2Urinary Bladder Neoplasms (Bladder Cancer)
08/2010 - 08/2009
2Kidney Neoplasms (Kidney Cancer)
07/2009 - 06/2008
2Lymphatic Metastasis
09/2008 - 12/2003
1Wounds and Injuries (Trauma)
03/2013
1Pain (Aches)
07/2011
1Carcinogenesis
01/2010
1Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
01/2010
1Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome)
10/2009
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
01/2009
1Disease Progression
11/2007
1Prostatic Diseases
02/2007

Drug/Important Bio-Agent (IBA)

30Prostate-Specific Antigen (Semenogelase)IBA
01/2022 - 01/2002
9Biomarkers (Surrogate Marker)IBA
01/2022 - 02/2003
9Proteins (Proteins, Gene)FDA Link
01/2010 - 10/2002
7Matrix Metalloproteinases (MMPs)IBA
02/2007 - 03/2002
6Alkaline PhosphataseIBA
11/2007 - 12/2003
5Collagen Type I (Type I Collagen)IBA
11/2007 - 12/2003
4Zoledronic Acid (Zometa)FDA Link
03/2022 - 11/2007
4MicroRNAs (MicroRNA)IBA
01/2021 - 01/2010
4Matrix Metalloproteinase InhibitorsIBA
02/2007 - 03/2002
4Ro 28-2653IBA
02/2007 - 03/2002
3AcidsIBA
12/2013 - 01/2004
3Indicators and Reagents (Reagents)IBA
02/2011 - 02/2007
3Messenger RNA (mRNA)IBA
07/2009 - 06/2008
3EnzymesIBA
09/2008 - 10/2006
3OsteoprotegerinIBA
10/2006 - 12/2003
2Vitamin DFDA LinkGeneric
03/2022 - 09/2016
2Sarcosine (Methylglycine)IBA
02/2011 - 07/2010
2Hormones (Hormone)IBA
04/2010 - 09/2005
2Transcription Factors (Transcription Factor)IBA
04/2010 - 01/2010
2DNA (Deoxyribonucleic Acid)IBA
01/2010 - 03/2004
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
10/2009 - 02/2003
2Tumor Biomarkers (Tumor Markers)IBA
07/2009 - 09/2008
2Metalloproteases (Metalloproteinases)IBA
11/2008 - 06/2008
2Matrix Metalloproteinase 7 (Matrilysin)IBA
11/2008 - 06/2008
2DisintegrinsIBA
11/2008 - 06/2008
2ImmunosorbentsIBA
09/2008 - 10/2006
2ProcollagenIBA
11/2007 - 09/2004
2OsteopontinIBA
09/2007 - 02/2007
2EstramustineFDA Link
02/2007 - 09/2005
2Tartrate-Resistant Acid PhosphataseIBA
10/2006 - 09/2004
2IsoenzymesIBA
10/2006 - 09/2004
2LycopeneIBA
08/2005 - 06/2004
2IronIBA
08/2005 - 06/2004
2RANK LigandIBA
09/2004 - 12/2003
1Cholecalciferol (Vitamin D3)FDA Link
03/2022
1hydroxide ionIBA
03/2022
1Calcitriol (Calcijex)FDA LinkGeneric
03/2022
125-hydroxyvitamin DIBA
09/2016
1CholesterolIBA
01/2016
1ThiosulfatesIBA
02/2015
1indoleIBA
01/2015
1Testosterone (Sustanon)FDA Link
07/2014
1maltotrioseIBA
12/2013
1gluconic acid (gluconate)FDA LinkGeneric
12/2013
1tricosanoic acidIBA
12/2013
1N'- formyl- 2- (5- nitrothiophen- 2- yl)benzothiazole- 6- carbohydrazideIBA
03/2013
1acrylic acid (acrylate)IBA
08/2012
1Chalcone (Benzalacetophenone)IBA
04/2011
1ChalconesIBA
04/2011
1RNA (Ribonucleic Acid)IBA
11/2010
1TARPIBA
01/2010
1Formaldehyde (Formol)FDA Link
01/2010
1ParaffinIBA
01/2010
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2010
1gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)IBA
01/2010
1Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
01/2010
1Glutathione S-Transferase piIBA
01/2010
1N-benzoyl-N-phenylhydroxylamineIBA
10/2009
1taurolidineIBA
08/2009
1Fatty Acid-Binding ProteinsIBA
07/2009
1Biological ProductsIBA
01/2009
1Cisplatin (Platino)FDA LinkGeneric
01/2009
1Serum Amyloid A Protein (Serum Amyloid A)IBA
09/2008
1Diphosphonates (Bisphosphonates)IBA
11/2007
1S100 Proteins (S 100 Protein)IBA
09/2007
1gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA
09/2007
1Tissue Kallikreins (Tissue Kallikrein)IBA
09/2007
1Alanine Transaminase (SGPT)IBA
09/2007
1Protein Isoforms (Isoforms)IBA
03/2007
1Procollagen Type IIBA
02/2007
1Pharmaceutical PreparationsIBA
02/2007
1AndrogensIBA
02/2007
1Etoposide (VP 16)FDA LinkGeneric
02/2007

Therapy/Procedure

17Prostatectomy (Retropubic Prostatectomy)
03/2022 - 05/2003
5Therapeutics
01/2010 - 11/2007
1Postoperative Care
07/2011
1Length of Stay
07/2011
1Cystectomy
08/2010
1Drug Therapy (Chemotherapy)
01/2009
1Combination Drug Therapy (Combination Chemotherapy)
01/2009